Pipeline

Binders for neurodegenerative and systemic amyloid disease

Each program pairs an engineered, disease-relevant amyloid target with binders designed by our AI models and tested in our lab.

Program status

TargetTherapeutic area
DiscoveryLead OpCandidate selectionIND-enabling
Owner
Tau fibril
Alzheimer’s
Candidate selection
UCSB & ProFoldBio
Tau FIA
Alzheimer’s
Lead optimization
UCSB & ProFoldBio
α-synuclein
Parkinson’s
Discovery
ProFoldBio
TTR
Cardiomyopathy
Discovery
ProFoldBio

How programs advance

Discovery

Engineer the target, design and screen binders, confirm initial hits.

Lead optimization

Improve affinity, specificity and developability of the best hits.

Candidate selection

Choose a development candidate based on efficacy and safety data.

IND-enabling

Complete the studies required before clinical trials.

Interested in partnering on a program?

We partner with pharma and biotech on co-development and licensing, and with academic groups on research. We also welcome conversations with investors.

Connect with us
2435 Elings Hall, Santa Barbara, CA 93106
+1 (805) 714-9560